AI-guided AAV Library Construction and Screening
In response to bespoke customer requirements, Porton Advanced and BioMap leverage state-of-the-art AI-driven AAV design solutions. These meticulously co-developed solutions enable the efficient creation and optimization of AAV libraries across 10+ serotypes. By incorporating point mutations, short peptide insertions, and fragment shuffling, we achieve exceptional transduction efficiency, precise tissue and organ targeting, and superior immune evasion capabilities.
AI-guided AAV Design Solution
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High-Precision
High-precision AAV property prediction and generalization capabilities, covering 10+ serotypes
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One-Click Design
User-friendly one-click AAV library design for simultaneous optimization of multiple propertiesing leads!
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Tailored Model
Tailored model fine-tuning with user data to further enhance prediction accuracy
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20M
AAV Viability Data
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10+
Tissue-Specific Libraries
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3B
Protein Data
Based on BioMap's
100B-Parameter Multimodal LLM
Multi-Objective Optimization Sequence Design Algorithms
- High Viability
- High Transduction Efficiency
- Tissue Targeting Specificity
- Immune Evasion Capability
*Representative Multi-objective Optimization Models
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Viability Model
Trained on 20 million AAV viability data, achieving SOTA prediction levels, and demonstrating generalization to
non-training-dataset serotypes and mutation regions. -
Tissue Targeting and
Transduction Efficiency ModellPre-trained on 10+ different tissue-specific libraries, ensuring efficient targeting and transduction capabilities across various tissues, improving the success rate of subsequent sequence validation.
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Immune Evasion
CapabilityTrained on extensive general protein data, effectively avoiding the generation of highly immunogenic fragments.
Construction, Screening, And Validation Services For AAV Capsid Library
Porton Advanced has extensive experience in constructing AAV capsid library plasmids with established AAV packaging systems, and various purification processes to ensure stable and efficient project delivery.
We conduct AAV capsid library screening, both in vivo (NHP, mouse) and in vitro (3D culture, organoid, solid-phase screening) as necessary
We use reporter genes or specific genes with barcode sequences for virus packaging.
We perform gene synthesis based on the candidate variant sequence and construct variant plasmids.
Identify candidate variants after multiple rounds of screening.
Additionally, we conduct animal studies or in vitro affinity testing, followed by NGS sequencing to analyze the variant targeting ability, etc.
